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VOLUME 50 , ISSUE 2 ( April-June, 2016 ) > List of Articles


Vitamin D reduces Exacerbation in Children with Asthma: A Systematic Review and Meta-analysis

Anil Chauhan, Nishant Jaiswal, Manvi Singh, Kiran Kumar Thumburu, Shailender Singh Chauhan, Sunil Dhatwalia, Mananda S Bhende, Meenu Singh

Citation Information : Chauhan A, Jaiswal N, Singh M, Thumburu KK, Chauhan SS, Dhatwalia S, Bhende MS, Singh M. Vitamin D reduces Exacerbation in Children with Asthma: A Systematic Review and Meta-analysis. J Postgrad Med Edu Res 2016; 50 (2):86-92.

DOI: 10.5005/jp-journals-10028-1198

Published Online: 01-06-2016

Copyright Statement:  Copyright © 2016; The Author(s).



The question whether treatment with vitamin D improves asthma exacerbations in children and adults still needs to be addressed.


Recent studies in children and adults found a higher prevalence of hypovitaminosis D associated with a higher severity of asthma and impaired pulmonary function. In asthmatic children, patients with vitamin D deficiency demonstrated increased airway hyperresponsiveness and corticosteroid requirements.


Of 469 records/studies identified through database searching, 5 studies were included in this systematic review. The overall pooled effect showed a significant reduction in acute asthma exacerbation in the vitamin D group (odds ratio 0.45, 95% confidence interval 0.22—0.93). There were no studies that focus on the quality of life.


This systematic review supports the role of vitamin D in reducing the number of asthma exacerbations in children but not in adults.

Clinical significance

The present systematic review demonstrates reduction in asthma exacerbations in children. Most of the asthma children are on inhaled corticosteroid, which poses a threat for its side effects. However, vitamin D having multiple functions in body could be used as an alternative therapy in asthmatic children. In adults, more trials are needed wherein the deficient individuals are supplemented with vitamin D and further assessed for asthma exacerbations. There is no harm in supplementation of vitamin D to deficient and insufficient asthmatic individuals.

How to cite this article

Chauhan A, Singh M, Jaiswal N, Thumburu KK, Agarwal A, Chauhan SS, Dhatwalia S, Bhende MS, Singh M. Vitamin D reduces Exacerbation in Children with Asthma: A Systematic Review and Meta-analysis. J Postgrad Med Edu Res 2016;50(2):86-92.

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