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VOLUME 50 , ISSUE 3 ( July-September, 2016 ) > List of Articles


Mean Platelet Volume and Platelet Distribution Width as Markers of Vascular Thrombosis in Type 2 Diabetes Mellitus

M Bhanukumar, Prasanna KH Ramaswamy, Naveen K Peddi, Vineetha B Menon

Citation Information : Bhanukumar M, Ramaswamy PK, Peddi NK, Menon VB. Mean Platelet Volume and Platelet Distribution Width as Markers of Vascular Thrombosis in Type 2 Diabetes Mellitus. J Postgrad Med Edu Res 2016; 50 (3):127-131.

DOI: 10.5005/jp-journals-10028-1204

Published Online: 01-12-2014

Copyright Statement:  Copyright © 2016; The Author(s).



The objective of the study was to determine the mean platelet volume (MPV) and platelet distribution width (PDW) in subjects with type 2 diabetes mellitus (type 2 DM) compared to subjects without type 2 DM and their correlation with fasting blood glucose, glycosylated hemoglobin (HbA1c), and duration of type 2 DM respectively.

Materials and methods

A prospective analytical case—control study was conducted involving 50 subjects with type 2 DM and 50 subjects without type 2 DM. The mean and standard deviation were estimated for both the groups separately and independent Student's “t”-test was used for evaluating the significant difference. The statistical evaluation was carried out at 95% confidence level.


Mean MPV and PDW in case group was significantly higher compared to control group (p < 0.005). Fasting blood glucose, HbA1c, and duration of type 2 DM did not significantly alter MPV or PDW.


The study concludes that MPV and PDW are significantly increased in patients with type 2 DM compared to patients without type 2 DM. Platelet volume indices are an important, simple, and cost-effective tool that should be used and explored extensively, especially in countries, such as India, for predicting the possibility of impending acute vascular events in patients with type 2 DM.

Clinical significance

This analytical method helps us to use MPV and PDW as early markers of vascular thrombosis.

How to cite this article

Bhanukumar M, Ramaswamy PKH, Peddi NK, Menon VB. Mean Platelet Volume and Platelet Distribution Width as Markers of Vascular Thrombosis in Type 2 Diabetes Mellitus. J Postgrad Med Edu Res 2016;50(3):127-131.

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  1. Arachidonic acid metabolism by platelets of differing size. Br J Haematol 1983 Mar;53(3):503-511.
  2. The Relationship of human platelet density to platelet age: platelet population labeling by monoamine oxidase inhibition. Blood 1989 Apr;73(5):1218-1225.
  3. Variation of class 1 HLA antigen expression among platelet density cohorts: a possible index of platelet age? Blood 1988 Feb;71(2):516-519.
  4. The relationship between megakaryocytes ploidy and platelet volume. Blood Cells 1989;15(1):108-121.
  5. Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol 2006;59:146-149.
  6. Macrovascular complications and their association factors among persons with type 2 diabetes mellitus. J Pak Med Assoc 2004 Feb;54(2):60-66.
  7. Pathogenesis of platelet dysfunction in diabetes: a fundamental and clinical text. Philadelphia (PA): Lippincott-Raven; 1996. p. 832-839.
  8. Platelet and stroke. Vasc Med 1999;4(3):165-172.
  9. Mean platelet volume in diabetes mellitus. Q J Med 1993 Nov;86(11):739-742.
  10. Platelet morphology, soluble P selectin and platelet P-selectin in acute ischaemic stroke. The West Birmingham Stroke Project. Thromb Haemost 2004 Dec;92:1342-1348.
  11. Circulating reticulated platelets in the early and late phases after ischaemic stroke and transient ischaemic attack. Br J Haematol 2004 Sep;126(6):861-869.
  12. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004 Dec;15(8):475-478.
  13. The effects of coronary artery disease severity on time-dependent changes in platelet activation indices in stored whole blood. J Thromb Thrombolysis 2008 Apr;25(2):135-140.
  14. Platelet reactivity in acute coronary syndromes: evidence for differences in platelet behaviour between unstable angina and myocardial infarction. Thromb Haemost 2001 Jun;85(6):989-994.
  15. Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest pain. Eur Heart J 1998 Jan;19(1):80-84.
  16. Role of mean platelet volume in triagging acute coronary syndromes. J Thromb Thrombolysis 2008 Aug;26(1):49-54.
  17. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J Diabetes Complications 2009 Mar-Apr;23(2):89-94.
  18. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004 May-Jun;18(3):173-176.
  19. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology 2011 Mar;16(2):86-89.
  20. Mean platelet volume in Type 2 diabetes mellitus. J Lab Physicians 2012;4(1):5-9.
  21. Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose and nondiabetic subjects. Singapore Med J 2008;49(2): 114-116.
  22. The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet Med 1997;14(Suppl 5):S1-S85.
  23. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991 Jun 1;88(11):4651-4655.
  24. Nitric oxide modulates the expression of monocyte chemoattractant protein 1 in cultured human endothelial cells. Circ Res 1995 Jun;76(6):980-986.
  25. Changing concepts of atherogenesis. J Intern Med 2000 Mar;247(3):349-358.
  26. Significance of chemokines and activated platelets in patients with diabetes. Clin Exp Immunol 2000 Sep;121(3):437-444.
  27. The role of oxidative stress and NF-kappa B activation in late diabetic complications. Biofactors 1999;10(2-3):157-167.
  28. Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta. J Clin Invest 1990 Mar;85(3):929-932.
  29. Topical hyperglycemia rapidly suppresses EDRF mediated vasodilation of normal rat arterioles. Am J Physiol 1993 Jul;265(1 Pt 2):H219-H225.
  30. Endothelium-dependent relaxation in aorta of BB rat. Diabetes 1987 Aug;36:978-981.
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