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VOLUME 52 , ISSUE 2 ( April-June, 2018 ) > List of Articles


Potential Application of Mesenchymal Stem Cells and Their Secretory Factors for Musculoskeletal Disorders: A Brief Review

Aditi Mahajan, Shalmoli Bhattacharyya

Keywords : Conditioned media, Mesenchymal stem cells, Muscle repair and regeneration, Musculoskeletal disorders, Secretome

Citation Information : Mahajan A, Bhattacharyya S. Potential Application of Mesenchymal Stem Cells and Their Secretory Factors for Musculoskeletal Disorders: A Brief Review. J Postgrad Med Edu Res 2018; 52 (2):73-82.

DOI: 10.5005/jp-journals-10028-1279

License: CC BY-NC 4.0

Published Online: 01-04-2019

Copyright Statement:  Copyright © 2018; The Author(s).


Musculoskeletal system accounts for the support, stability, and locomotion or movement of the human body. Musculoskeletal disorders (MSDs) include any injury, damage or disorder of muscles, bone, cartilage, tendons, ligaments, and joints in upper/ lower limbs or the back. Mesenchymal stem cells (MSCs) are being increasingly used for a variety of MSDs owing primarily to their excellent regenerative potential. The major mechanism through which MSCs participate in tissue repair is by the secretion of a broad repertoire of molecules which serve a myriad of biological functions. These molecules, collectively called as secretome, provide a way for cell free therapy by surpassing the limitations of cellular therapy and at the same time, provide equivalent benefits to the recipient. Cell free therapy utilizing only the secretome of MSCs has gained popularity in the past few years, and various preclinical studies have employed either the soluble factors, or vesicles, or complete secretome not only for disorders of musculoskeletal system but also of central nervous system, cardiac system, circulatory system, and autoimmunity. However, the exact mechanism of action of many of these molecules still remains to be discovered. Therefore, achieving an optimal outcome of tissue function restoration by designing a cell free therapeutic regimen using only secretome remains a major challenge. While acknowledging the potential of MSC secretome in other areas of regenerative medicine, this review will elucidate the regenerative potential of MSCs and their secretome in MSDs.

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