Orthobiologics are the biologically derived materials from the body to promote the repair and regeneration of muculoskeletal tissues. Orthobiologics has got special attention in recent past and become the focus of study of researchers in various traumatic and nontraumatic spinal pathologies. Efforts were made to develop materials capable of bone formation and which encourage healing of fractures. When they are used in higher concentrations than normally present in the body, they can potentially help speed up the healing process. The substances which are considered to be orthobiologics are: bone grafts, autologous blood, autologous conditioned serum (ACS), platelet-rich plasma (PRP), growth factors, and stem cells.
Various clinical and animal studies have shown variable results. This review gives an outline regarding the currently available clinical information and application of orthobiologics in various spinal pathologies for therapeutic use.
OrthoInfo. Available from: http://orthoinfo.aaos.org/topic.cfm?topic=A00525 [cited 2017 Dec 13].
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