Journal of Postgraduate Medicine, Education and Research

Register      Login

VOLUME 53 , ISSUE 3 ( July-September, 2019 ) > List of Articles


Brucellosis: A Case Report and Literature Review

Mahnaz Hakeem, Sana Saeed

Keywords : Brucellosis, Pyrexia of unknown origin, Zoonotic disease

Citation Information : Hakeem M, Saeed S. Brucellosis: A Case Report and Literature Review. J Postgrad Med Edu Res 2019; 53 (3):126-127.

DOI: 10.5005/jp-journals-10028-1328

License: CC BY-NC 4.0

Published Online: 01-09-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Brucellosis is a major cause of febrile illnesses in areas with high exposure to animals or unpasteurized milk and dairy products. It may manifest with multisystem clinical presentations. Our patient was a six-year-old boy who was presented in emergency room with a prolonged history (3 weeks) of high-grade fever with chills, not responding to antibiotics. Upon inquiry, the history revealed the use of unpasteurized goat milk and contact with goats at home. Upon investigation, serum antibodies for brucellosis were raised (1:640). He was started on combination therapy with rifampicin and doxycycline. He became afebrile within two days so was discharged home. We found that an ineffective history could lead to delay in diagnosis and management. Clinicians should have high index of suspicion for brucellosis in children.

  1. GUL ST, Khan A. Epidemiology and epizootology of brucellosis: a review. Pakistan Vet J 2007;27(3):145–151.
  2. Zhen Q, Lu Y, et al. Asymptomatic brucellosis infection in humans: implications for diagnosis and prevention. Clin Microbiol Infect 2013;19(9):E395–E397.
  3. Mantur BG, Akki AS, et al. Childhood brucellosis–a microbiological, epidemiological and clinical study. J Trop Pediatr 2004;50(3):153–157.
  4. Mukhtar F. Brucellosis in a high risk occupational group: seroprevalence and analysis of risk factors. J Pak Med Assoc 2010;60(12):1031–1034.
  5. Shaalan MA, Memish ZA et al. Brucellosis in children: clinical observations in 115 cases. Int J Infect Dis 2002;6(3):182–186.
  6. Lubani MM, Dudin KI, et al. Neurobrucellosis in children. Pediatr Infect Dis J 1989;8(2):79–82.
  7. Gotuzzo E, Carrillo C, et al. An evaluation of diagnostic methods for brucellosis–the value of bone marrow culture. J Infect Dis 1986;153(1):122–125.
  8. Budnik I, Fuchs I, et al. Unusual presentations of pediatric neurobrucellosis. Am J Trop Med Hyg 2012;86(2):258–260.
  9. Sachdev A, Vohra R, et al. Acute brucellosis of childhood: a case report with unusual features. Indian Pediatr 2001;38(12):1421–1425.
  10. Mile B, Valerija K, et al. Doxycycline-rifampin versus doxycycline-rifampin-gentamicin in treatment of human brucellosis. Trop Doct 2012;42(1):13–17.
  11. Bouza E, Garcia de la Torre M, et al. Brucellar meningitis. Rev Infect Dis 1987;9(4):810–822.
  12. Farhan N, Khan EA, et al. Neurobrucellosis: A report of two cases. J Pak Med Assoc 2017 Nov;67(11):1762–1763.
  13. Aghdam MK, Davari K, et al. Recurrent epistaxis and bleeding as the initial manifestation of brucellosis. Acta Medica Iranica 2016;54(3):218–219.
  14. Yaman Y, Gözmen S, et al. Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: report of three cases. J Infect Dev Ctries 2015 Oct 29;9(10):1172–1176
  15. Metin O, Teke TA, et al. A case of brucellosis mimicking Crimean-Congo hemorrhagic fever. J Infect Public Health 2015;8(3):302–304.
  16. Akbayram S, Dogan M, et al. Thrombotic thrombocytopenic purpura in a case of brucellosis. Clin Appl Thromb Hemost 2011;17(3):245–247.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.