Systemic Lupus Erythematosus Presenting with Thrombotic–Thrombocytopenic Purpura-like Syndrome and Catatonia

Gaurav Vohra; Jasmine Sethi

doi:10.5005/jp-journals-10028-1332

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Systemic Lupus Erythematosus Presenting with Thrombotic–Thrombocytopenic Purpura-like Syndrome and Catatonia

Gaurav Vohra, Jasmine Sethi

Keywords : Catatonia, Systemic lupus erythematosus, Thrombotic microangiopathy, Thrombotic–Thrombocytopenic purpura

Citation Information : Vohra G, Sethi J. Systemic Lupus Erythematosus Presenting with Thrombotic–Thrombocytopenic Purpura-like Syndrome and Catatonia. J Postgrad Med Edu Res 2019; 53 (4):158-159.

DOI: 10.5005/jp-journals-10028-1332

License: CC BY-NC 4.0

Published Online: 01-06-2018

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Abstract

Systemic lupus erythematosus (SLE) can present with thrombotic microangiopathy (TMA), and differentiating this from thrombotic thrombocytopenic purpura can be a challenging task. Though thrombotic–thrombocytopenic purpura (TTP) is a type of TMA demonstrating a severely reduced activity of VWF, cleaving protease ADAMTS 13 can differentiate it from other causes of TMA. Association of TTP-like TMA and catatonia in lupus is not described in literature. Neuropsychiatric lupus presenting as catatonia is uncommon. Here we describe a 41-year-old female who was presented with TTP-like TMA and catatonic symptoms, which improved with plasma-exchange, benzodiazepines, and immunosuppression.

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