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VOLUME 55 , ISSUE 1 ( January-March, 2021 ) > List of Articles


Endoscopic Management of Obesity 2020

Truptesh H Kothari

Keywords : Aspiration therapy, Endoscopic bariatric therapy, Endoscopic sleeve gastroplasty, Intragastric balloons, Obesity, Transoral outlet reduction endoscopy

Citation Information : Kothari TH. Endoscopic Management of Obesity 2020. J Postgrad Med Edu Res 2021; 55 (1):2-7.

DOI: 10.5005/jp-journals-10028-1426

License: CC BY-NC 4.0

Published Online: 01-03-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Obesity is a disease of energy homeostasis with accumulation of excessive fat leading to negative health effects associated with increased morbidity and mortality. The World Health Organization (WHO) estimates approximately 700 million people worldwide in the obese category. Life expectancy due to obesity is decreased by 6–7 years. A body mass index (BMI) of 30–35 kg/m2 reduces life expectancy by 2–4 years, while BMI >40 kg/m2 reduces life expectancy by 10 years. In this manuscript, we will review the global updates on the burden of obesity, current management of obesity, evolution of bariatric endotherapy, various aspects of bariatric endotherapy, and literature review of the data supporting the bariatric endotherapy.

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  1. Obesity: preventing and managing the global epidemic Report of a WHO consultation. World Health Organ Tech Rep Ser 2000;894(i-xii):1–253.
  2. Peeters A, Barendregt JJ, Willekens F, et al. Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Ann Intern Med 2003;138(1):24–32. DOI: 10.7326/0003-4819-138-1-200301070-00008.
  3. Whitlock G, Lewington S, Sherliker P, et al. Body mass index and cause specific mortality in 900000 adults: collaborative analyses of 57 prospective studies. Lancet 2009;373(9669):1083–1096. DOI: 10.1016/S0140-6736(09)60318-4.
  4. Ogden CL, Carroll MD, Fryar CD, et al. Prevalence of obesity among adults and youth: United States, 2011-2014. NCHS Data Brief 2015;219:1–8.
  5. World Health Organization. Fact Sheet. Obesity and Overweight -
  6. World Health Organization. Fact Sheet. Obesity and Overweight
  7. Ma IT, Madura 2nd JA. Gastrointestinal complications after bariatric surgery. Gastroenterol Hepatol (N Y) 2015;11(8):526–535.
  8. Abu Dayyeh BK, Kumar N, Edmundowicz SA, et al. ASGE bariatric endoscopy task force systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting endoscopic bariatric therapies. Gastrointest Endosc 2015;82(3):425–438.e5. DOI: 10.1016/j.gie.2015.03.1964.
  9. Kumar N. Weight loss endoscopy: development, applications, and current status. World J Gastroenterol 2016;22(31):7069–7079. DOI: 10.3748/wjg.v22.i31.7069.
  10. Yanovski SZ, Yanovski JA. Long-term drug treatment for obesity. JAMA 2014;311(1):74. DOI: 10.1001/jama.2013.281361B E. The effectiveness and risks of bariatric surgery an updated systematic review and meta-analysis, 2003-2012.
  11. Mafort TT, Madeira E, Madeira M, et al. Six-month intragastric balloon treatment for obesity improves lung function, body composition, and metabolic syndrome. Obes Surg 2013;24(2):232–240. DOI: 10.1007/s11695-013-1061-5.
  12. Ponce J, Woodman G, Swain J, et al. The REDUCE pivotal trial: a prospective, randomized controlled pivotal trial of a dual intra-gastric balloon for the treatment of obesity. Surg Obes Rel Disea 2015;11(4):874–881. DOI: 10.1016/j.soard.2014.12.006.
  13. Sullivan S, Stein R, Jonnalagadda S, et al. Aspiration therapy leads to weight loss in obese subjects: a pilot study. Gastroenterology 2013;145(6):1245–1252. DOI: 10.1053/j.gastro.2013.08.056.
  14. Thompson CC, Abu Dayyeh BK, Kushner R, et al. Percutaneous gastrostomy device for the treatment of class II and class III obesity: results of a randomized controlled trial. Am J Gastroenterol 2017;112(3):447–457. DOI: 10.1038/ajg.2016.500.
  15. Lopez-Nava G, Sharaiha RZ, Vargas EJ, et al. Endoscopic sleeve gastroplasty for obesity: a multicenter study of 248 patients with 24 months follow-up. Obes Surg 2017;27(10):2649–2655. DOI: 10.1007/s11695-017-2693-7.
  16. Kumar N, Thompson CC. Mo2038 transoral outlet reduction (TORe) for weight regain after gastric bypass: Long-term follow-up and number needed to treat. Gastroenterology 2014;146(5). DOI: 10.1016/s0016-5085(14)62627.
  17. Truptesh K, Paridhi M, Shivangi K, et al. Endoscopic bariatric interventions in the management of obesity: the era of non-surgical management. Frontiers in Endoscopy, Series # 33 2017;XLI(1):14–23.
  18. Ryou M, McQuaid KR, Thompson CC, et al. ASGE endovators summit: defining the role and value of endoscopic therapies in obesity management. Gastrointest Endosc 2017;86(5):757–767. DOI: 10.1016/j.gie.2017.08.004.
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