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VOLUME 55 , ISSUE 1 ( January-March, 2021 ) > List of Articles


Nonalcoholic Fatty Liver Disease and Obesity

Arka De, Ajay Duseja

Keywords : Fatty liver, Hepatic steatosis, Metabolic dysfunction-associated fatty liver disease, Metabolic syndrome, Nonalcoholic fatty liver disease, Nonalcoholic steatohepatitis

Citation Information : De A, Duseja A. Nonalcoholic Fatty Liver Disease and Obesity. J Postgrad Med Edu Res 2021; 55 (1):27-35.

DOI: 10.5005/jp-journals-10028-1430

License: CC BY-NC 4.0

Published Online: 01-03-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


The ability of the body to store energy in adipose tissue for utilization during exigency has helped us cope with periodic food shortages through much of human history. The easy availability of calorie-dense food and a sedentary lifestyle has, however, resulted in this becoming a bane with adverse health consequences. Both obesity and nonalcoholic fatty liver disease (NAFLD) are lifestyle diseases that have emerged as substantial public health problems globally and in India. Obesity is an important risk factor for NAFLD and its severe form of nonalcoholic steatohepatitis (NASH). Weight loss is the only proven beneficial intervention in NAFLD/NASH. This provides a unique opportunity for managing NASH in obese patients. Lifestyle interventions including dietary modifications and exercise should be the primary modality for weight loss and have shown to be feasible and effective in obese patients with NASH. Although not yet indicated for the management of NASH per se, anti-obesity drugs and bariatric procedures may be considered in selected patients if otherwise indicated and may lead to indirect hepatic benefits secondary to weight loss.

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