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VOLUME 55 , ISSUE 1 ( January-March, 2021 ) > List of Articles


Nonalcoholic Fatty Liver Disease in Children: Spectrum and Consequences

Aradhana Aneja, Sadhna B Lal

Keywords : Advances in pNAFLD, Children, Nonalcoholic fatty liver disease

Citation Information : Aneja A, Lal SB. Nonalcoholic Fatty Liver Disease in Children: Spectrum and Consequences. J Postgrad Med Edu Res 2021; 55 (1):39-52.

DOI: 10.5005/jp-journals-10028-1429

License: CC BY-NC 4.0

Published Online: 01-03-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Nonalcoholic fatty liver disease (NAFLD) has emerged as the commonest liver disease in children. The entire spectrum of NAFLD from simple steatosis to inflammation and fibrosis is seen in children. Pediatric NAFLD (pNAFLD) is most common in preadolescent and adolescent children and has the potential to cause severe liver-related as well as cardiovascular morbidity in young adulthood. The natural history of pNAFLD needs further elucidation. However, early diagnosis is imperative to prevent serious later outcomes. Lifestyle modification through diet and exercise remains the cornerstone in the management of pNAFLD. There is a great potential for the development of noninvasive biomarkers for diagnosis and novel pharmacotherapy to become available for the treatment of pNAFLD shortly.

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