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VOLUME 58 , ISSUE 1 ( January-March, 2024 ) > List of Articles


Lipid Profile and Total Antioxidant Status in Major Depressive Disorder Patients in North Indian Tertiary Care Hospital: A Case Control Study

Piyush Pathak, Sandeep Kaur, Sandeep Grover, Sant Ram

Keywords : Antioxidants, Cholesterol, Lipid profile, Major depressive disorder, Triglycerides

Citation Information : Pathak P, Kaur S, Grover S, Ram S. Lipid Profile and Total Antioxidant Status in Major Depressive Disorder Patients in North Indian Tertiary Care Hospital: A Case Control Study. J Postgrad Med Edu Res 2024; 58 (1):19-23.

DOI: 10.5005/jp-journals-10028-1655

License: CC BY-NC 4.0

Published Online: 06-02-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Aims and background: Major depressive disorder (MDD) is the most common mental health disorder. It is a multifactorial disease and the pathophysiology is not clear, which results in fewer available options for treatment and more treatment-resistant cases. The development of early diagnostic and prognostic markers will help in the reduction of the burden of this disease. Oxidative stress plays an important role in depression and it is evident that antioxidant effects are exerted by many treatment modalities available for depression. Lipids have a role in inter- and intraneuronal functions of the brain, they can also be developed as markers for MDD. Materials and methods: In this study, we compared serum antioxidant status and serum lipid profile in MDD patients and healthy controls. A total of 30 MDD patients and 30 healthy controls were included in the study. Serum antioxidant level and serum lipid profile were done using a kit-based method on an autoanalyzer. Results: The level of antioxidants [mean ± standard deviation (SD)] in controls was 1.332 ± 0.215 mmol/L and in MDD patients was 1.399 ± 0.298 mmol/L, the difference was not significant. The level of total cholesterol in controls was 169.203 ± 31.114 mg/dL and in MDD patients was 193.080 ± 38.876 mg/dL, the difference was statistically significant (p = 0.011). The difference in low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG) levels was insignificant between healthy controls and MDD patients. Conclusion: Mixed findings from our study and the various literature suggest that there is a complex association between MDD, antioxidants, and lipid profile, and extensive study is needed in the field. Clinical significance: The study will be helpful in finding biomarkers for MDD.

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