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VOLUME 58 , ISSUE 2 ( April-June, 2024 ) > List of Articles

CASE REPORT

An Unusual Case of Extensive Dry Gangrene with Mummification of Face, Lower Limbs, and Autoamputation of Nose in Sepsis: A Case Report

Ajeet K Chaurasia, Poonam Gupta, Naincy Purwar

Keywords : Autoamputation, Case report, Dry gangrene, Mummification, Sepsis, Symmetrical peripheral gangrene

Citation Information : Chaurasia AK, Gupta P, Purwar N. An Unusual Case of Extensive Dry Gangrene with Mummification of Face, Lower Limbs, and Autoamputation of Nose in Sepsis: A Case Report. J Postgrad Med Edu Res 2024; 58 (2):76-79.

DOI: 10.5005/jp-journals-10028-1666

License: CC BY-NC 4.0

Published Online: 05-07-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Aim and background: The case is exceptional in view of its rarity, lack of medical literature, unfamiliar clinical presentation, and devastating disease course. Case description: An 80-year-old male with extensive dry gangrene resulting from disseminated intravascular coagulation (DIC) in urosepsis due to Escherichia coli. The disease course was devastating, and the patient pleaded for euthanasia due to his debilitating illness, which was denied. Diagnosis: Symmetrical peripheral gangrene (SPG) in sepsis with involvement of face and lower limbs and sparing of upper limbs. Interventions: Strict medical management in the intensive care unit, and thrombolysis was attempted. Outcomes: The patient succumbed to the disease within 2 months of the onset of illness. Clinical significance: Gangrene in sepsis-associated DIC can also involve the face, and the definition of SPG may need an expansion to accommodate that. It is a rapidly progressive condition with a high mortality rate, and a formal consensus needs to be established for appropriate diagnosis and management.


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  1. Shimbo K, Yokota K, Miyamoto J, et al. Symmetrical peripheral gangrene caused by septic shock. Case Reports Plast Surg Hand Surg 2015;2:53–56. DOI: 10.3109/23320885.2015.1041529
  2. Akamatsu S, Kojima A, Tanaka A, et al. Symmetric peripheral gangrene. Anesthesiology 2013;118:1455. DOI: 10.1097/ALN.0b013e31826e05a7
  3. Parmar MS. Symmetrical peripheral gangrene: a rare but dreadful complication of sepsis. CMAJ 2002;167:1037–1038. PMID: 12403749.
  4. Foead AI, Mathialagan A, Varadarajan R, et al. Management of symmetrical peripheral gangrene. Indian J Crit Care Med 2018,22:870–874. DOI: 10.4103/ijccm.IJCCM_379_18
  5. Hayes MA, Yau EH, Hinds CJ, et al. Symmetrical peripheral gangrene: association with noradrenaline administration. Intensive Care Med 1992;18:433–436. DOI: 10.1007/BF01694349
  6. Sharma BD, Kabra SR, Gupta B. Symmetrical peripheral gangrene. Trop Doct 2004;34:2–4. DOI: 10.1177/004947550403400102
  7. Tsai Pai MA, Chien SW, Kuo YC, et al. Symmetrical peripheral gangrene after using high-dose inotropes. Acta Nephrologica 2013;27:48–51. DOI: 10.6221/AN.2012007
  8. Hutchison J. Severe symmetrical gangrene of the extremities. Br Med J 1891;2:8–9.
  9. Davis MD, Dy KM, Nelson S. Presentation and outcome of purpura fulminans associated with peripheral gangrene in 12 patients at Mayo Clinic. J Am Acad Dermatol 2007;57:944–956. DOI: 10.1016/j.jaad.2007.07.039
  10. Ghosh SK, Bandyopadhyay D, Ghosh A. Symmetrical peripheral gangrene: a prospective study of 14 consecutive cases in a tertiary-care hospital in eastern India. J Eur Acad Dermatol Venereol 2010;24:214–218. DOI: 10.1111/j.1468-3083.2009.03329.x
  11. Tiwary SK, Shankar R, Khanna R, et al. Symmetrical peripheral gangrene. Int J Surg 2006;7:(2). DOI: 10.5580/1493
  12. Karunatilaka DH, De Silva JR, Ranatunga PK, et al. Idiopathic purpura fulminans in dengue hemorrhagic fever. Indian J Med Sci 2007;61:471–473. PMID: 17679737.
  13. Perera TB, Murphy-Lavoie HM. Purpura fulminans. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024.
  14. Radić M, Martinović Kaliterna D, Radić J. Drug-induced vasculitis: a clinical and pathological review. Neth J Med 2012;70(1):12–17. PMID: 22271809.
  15. Tripathy S, Rath B. Symmetric peripheral gangrene: catch it early! J Emerg Trauma Shock 2010;3:189–190. DOI: 10.4103/0974-2700.62119
  16. McGouran RC, Emmerson GA. Symmetrical peripheral gangrene. Br Heart J 1977;39:569–572. DOI: 10.1136/hrt.39.5.569
  17. Ghosh SK, Bandyopadhyay D. Symmetrical peripheral gangrene. Indian J Dermatol Venereol Leprol 2011;77:244–248. DOI: 10.4103/0378-6323.77481
  18. Levi M, Toh CH, Thachil J, et al. Guidelines for the diagnosis and management of disseminated intravascular coagulation. Br J Haematol 2009;145:24–33. DOI: 10.1111/j.1365-2141.2009.07600.x
  19. Lesesve JF, Martin M, Banasiak C. Schistocytes in disseminated intravascular coagulation. Int J Lab Hematol 2014;36(4):439–443. DOI: 10.1111/ijlh.12168
  20. Boral BM, Williams DJ, Boral LI. Disseminated intravascular coagulation. Am J Clin Pathol 2016;146(6):670–680. DOI: 10.1093/ajcp/aqw195
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