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VOLUME 46 , ISSUE 4 ( October-December, 2012 ) > List of Articles

RESEARCH ARTICLE

A Comparative Analysis of the Efficacy and Safety of fixed Combinations of Latanoprost/Timolol vs Dorzolamide/Timolol in Primary Open Angle Glaucoma or Ocular Hypertension

Sukhsagar Ratol, Rani Walia, Mridu Chaudhry

Citation Information : Ratol S, Walia R, Chaudhry M. A Comparative Analysis of the Efficacy and Safety of fixed Combinations of Latanoprost/Timolol vs Dorzolamide/Timolol in Primary Open Angle Glaucoma or Ocular Hypertension. J Postgrad Med Edu Res 2012; 46 (4):172-176.

DOI: 10.5005/jp-journals-10028-1039

Published Online: 01-09-2014

Copyright Statement:  Copyright © 2012; The Author(s).


Abstract

Background

Glaucoma is a leading cause of irreversible blindness. The fundamental problem in medical management of glaucoma is of patient compliance. An ideal drug or a drug combination is needed to slow the progression of this majorly symptomless disease.

Aim

To compare the efficacy and tolerability of the fixed combination latanoprost and timolol instilled once daily in the evening vs fixed combination of dorzolamide and timolol instilled twice daily in primary open angle glaucoma or ocular hypertension.

Materials and methods

A 12-week, randomized, open, parallel group study including 50 patients with primary open angle glaucoma or ocular hypertension was conducted at a tertiary care hospital. Patients were randomized to group 1, (fixed combination (FC) latanoprost and timolol eye drops, once daily in evening) and group 2, (FC dorzolamide and timolol eye drops, twice daily). At baseline, 2, 4 and 12 weeks, IOP was recorded at 9 AM and 12 noon. The difference in IOP reduction in two treatment groups from baseline to 12 weeks was the main outcome measure.

Results

Mean diurnal IOP was similar at baseline for both groups. Mean reduction in IOP from baseline to 12 weeks was 9.92 mm Hg (p = 0.001) in group 1 and 9.22 (p = 0.001) in group 2. The reduction in IOP in both groups 1 and 2 was statistically significant at all time intervals. There was a statistically significant advantage for group 1 at 12 weeks for both time readings (p = 0.013 and 0.002 respectively) as compared to group 2.

Conclusion

The fixed combination of latanoprost and timolol was more effective than that of dorzolamide and timolol in reducing mean diurnal IOP and both treatments were well tolerated. To confirm further such studies are required.

How to cite this article

Ratol S, Walia R, Chaudhry M. A Comparative Analysis of the Efficacy and Safety of fixed Combinations of Latanoprost/Timolol vs Dorzolamide/Timolol in Primary Open Angle Glaucoma or Ocular Hypertension. J Postgrad Med Edu Res 2012;46(4):172-176.


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  1. Glaucomatous optic neuropathy. Am J Ophthalmol 1992;113(4):447-52.
  2. Number of people with glaucoma worldwide. Br J Ophthalmol 1996;80:389-93.
  3. Global data on visual impairment in the year 2002. Bull World Health Organization 2004;82:844-51.
  4. Glaucoma. Lancet 2011 Apr 16;377(9774):1367-77.
  5. Glaucoma in India: Estimated burden of disease. J Glaucoma 2010 Aug;19(6):391-97.
  6. Biochemical abnormalities in the aqueous in chronic open angle glaucoma. Ophthalmic Surg 1987 Nov; 18(11):792-95.
  7. A rationale for lowering intraocular pressure in Glaucoma. Surv Ophthalmol 2001;45(4):S335-36.
  8. Pharmacological therapy for Glaucoma. Drugs 2000 Mar;59(3):411-34.
  9. Role of fixed combinations in the management of open-angle glaucoma. Expert Rev Pharmacoecon Outcomes Res 2011 Feb;11(1):91-99.
  10. The costs of treating glaucoma with combinations of topical drugs in Spain. Eur J Ophthalmol 2008 Jan-Feb;18(1):52-59.
  11. Latanoprost and timolol combination therapy vs monotherapy: 1-year randomized trial. Arch Ophthalmol 2002;120(7):915-22.
  12. Long-term effect of latanoprost/timolol fixed combination in patients with glaucoma or ocular hypertension: A prospective, observational, noninterventional study. BMC Ophthalmol 2010 Sep 8;10:21
  13. Safety, tolerability and efficacy of fixed combination therapy with dorzolamide hydrochloride 2% and timolol maleate 0.5% in glaucoma and ocular hypertension. Clin Ophthalmol 2010 Nov 22;4:1331-46.
  14. Efficacy and safety of fixed combinations of latanoprost/timolol and dorzolamide/timolol in open-angle glaucoma or ocular hypertension. Eye 2010;24: 1234-42.
  15. Global data on visual impairment in the year 2002. Bull World Health Organ 2004;82: 844-51.
  16. Efficacy and safety of fixed combinations latanoprost/timolol versus dorzolamide/timolol in patients with elevated intraocular pressure. Ophthalmology 2004 Feb;111(2):276-82.
  17. Dorzolamide/timolol fixed combination versus latanoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertension. Curr Eye Res 2008 Feb;33(2):163-68.
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