Introduction: The role of vitamin D in the development of bones is well known and documented. It also helps in preserving the oral structures, consisting of mainly the teeth and supporting structures. This is the only vitamin which is available through natural sunlight. It is the only vitamin which is found naturally in cod liver oil and butterfat.
Material and methodology: The material presented in this review is a brief summary of the beneficial effects of vitamin D in various conditions, with major emphasis on dental caries, periodontal disease, the genetic basis of vitamin D and positive effect of vitamin D in the immune-compromised population.
Results: Vitamin D is also known as the antirachitic factor as it prevents the occurrence of rickets in adults and osteomalacia in children. However, vitamin D3 itself is biologically inert when converted to its active form, is found to be extremely beneficial in various conditions.
Conclusion: This review article focuses on various synergistic effects of vitamin D on oral health by searching a number of published articles from EBSCOhost database.
Gorham ED, Garland CF, Garland FC, et al. Optimal Vitamin D status for colorectal cancer prevention: A quantitative meta analysis. Am J Prev Med 2007;32(3):210-216.
Skinner HG, Michaud DS, Giovannucci E, et al. Vitamin D intake and the risk for pancreatic caneer in two cohort studies. Cancer Epidemiol Biomarkers Prev 2006;15(9):1688-1695.
Giovannucci E, Liu Y, Rimm EB, et al. Prospective study of predictors of Vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst 2006;98(7):451-459.
Moore C, Murphy MM, Keast DR, et al. Vitamin D Intake in the United States. J Am Diet Assoc 2004;104(6):980-983.
Ross AC, Taylor CL, Yaktine AL, et al. Dietary References Intakes for Calcium and Vitamin D. Washington (DC); National Academies Press (US): 2011.
Miley DD, Garcia MN, Hildebolt CF, et al. Cross-sectional study of Vitamin D and calcium supplementation effects on chronic periodontitis. J Periodontol 2009;80(9):1433-1439.
Garcia MN, Hildebolt CF, Miley DD, et al. One-year effects of Vitamin D and calcium supplementation on chronic periodontitis. J Periodontol 2011;82(1):25-32.
Deluca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004;80(6):1689s-1696s.
Yoshihara A, Sugita N, Yamamoto K, et al. Analysis of Vitamin D and FcY Receptor polymorphisms in Japanese patients with Generalized Early Onset Periodontitis. J Dent Res 2001;80(12):2051-2054.
Grenier D; Morin MP, Fournier-LJ, et al. Vitamin D inhibits the growth of and virulence factor gene expression by Porphyromonasgingivalis and blocks activation of the nuclear factor kappa B transcription factor in monocytes. J Periodontal Res 2016;51(3):359-365.
Schulze-SU, Dietrich T, Wu C, et al. Systemic vitamin D supplementation and local bone formation after maxillary sinus augmentation–a randomized, double-blind, placebo-controlled clinical investigation. Clin Oral Implants Res 2016;27(6):701-706.
Sahli MW, Wactawski-Wende J, Ram PK, et al. Association of Plasma 25-Hydroxyvitamin D concentrations and pathogenic oral bacteria in postmenopausal females. J Periodontol 2014;85(7):944-955.
Nociti FHJr, Foster BL, Tran AB, et al. Vitamin D represses dentin matrix protein 1 in cementoblasts and osteocytes. J Dent Res 2014;93(2): 148- 154.
Herzog K, Scott JM, Hujoel P, et al. Association of Vitamin D and dental caries in children: Findings from the National Health and Nutrition examination survey, 2005-2006. J Am Dent Assoc 2016;147(6): 413-420.
Antonenko O, Bryk G, Brito G, et al. Oral health in young women having a low calcium and Vitamin D nutritional status. Clin Oral Investig 2015;19(6):1199-1206.
Zhou X, Han J, Song Y, et al. Serum levels of 25-hydroxy vitamin D, oral health and chronic obstructive pulmonary disease. J Clin Periodontol 2012;39(4):350-356.
Alshouibi EN, Kaye EK, Cabral HJ, et al. Vitamin D and periodontal health in older men. J Dent Res 2013;92(8):689-693.
Hiremath VP, Bhasker Rao CB, Naik V, et al. Anti inflammatory effect of Vitamin D on gingivitis: A dose–response randomized control trial. Oral Health Prev Dent 2013;11:61-69.
Schroth RJ, Rabban R, Loewen G, et al. Vitamin D and dental caries in children. J Dent Res 2016;95(2):173-179.
Chantarangsu S, Sura T, Mongkornkarn S, Donsakul K, et al. Vitamin Dreceptor gene polymorphism and smoking in the risk of chronic periodontitis. J Periodontol 2016;87(111):13431.
Abreu OJ, Tatakis DN, Elias-Boneta AR, et al. Low Vitamin D status strongly associated with periodontitis in Puerto Rican adults. BMC Oral Health 2016;16(1):89.
Pavlesen S, Mai X, Wactawski-Wende J, et al. Vitamin D status and tooth loss in postmenopausal females: The buffalo osteoporosis and periodontal disease (Osteo Perio) study. J Periodontol 2016;87(8): 852-863.
Khan FR, Ahmad T, Hussain R, et al. A randomized controlled trial of Oral Vitamin D supplementation in pregnancy to improve maternal Periodontal health and birth weight. Journal of International Oral Health 2016;8(6):657-665.
Lee HJ, Je DI, Won SJ, et al. Association between Vitamin D deficiency and periodontal status in current smokers. Community Dent Oral Epidemiol 2015;43(5):471-478.
Antonoglou, GN, Suominen AL, Knuuttila M, et al. Associations between serum 25-hydroxyvitamin D and periodontal pocketing and gingival bleeding: results of a study in a non-smoking population in Finland. J Periodontol 2015;86(6):755-765.
Millen AE, Andrews CA, LaMonte MJ, et al. Vitamin D Status and 5-year changes in Periodontal Disease measures among postmenopausal women: the Buffalo Osteo Perio Study. J Periodontol 2014;85(10): 1321-1332.
Millen AE, Hovey KM, LaMonte MJ, et al. Plasma 25-Hydroxyvitamin D concentrations and periodontal disease in postmenopausal women. J Periodontol 2013;84(9):1243-1256.
Sroussi HY, Miller JB, French AL, et al. Association among Vitamin D, oral candidiasis and calprotectinemia in HIV. J Dent Res 2012;91(7): 666-670.