Journal of Postgraduate Medicine, Education and Research

Register      Login

VOLUME 56 , ISSUE 1 ( January-March, 2022 ) > List of Articles

REVIEW ARTICLE

Decrypting the Role of Systemic Illnesses in Developmental Defects of Enamel

Sanjeev Singh, Mrinalini Rathore

Keywords : Dental, Developmental defects, Enamel, Hard tissue, Hypomineralization, Hypoplasia

Citation Information : Singh S, Rathore M. Decrypting the Role of Systemic Illnesses in Developmental Defects of Enamel. J Postgrad Med Edu Res 2022; 56 (1):21-28.

DOI: 10.5005/jp-journals-10028-1564

License: CC BY-NC 4.0

Published Online: 19-02-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

The development of dental hard tissues involves a very intricate mechanism beginning in utero and continuing up to the first few years of life. The developmental processes involved at the cellular level are extremely sensitive to genetic and environmental factors. Any systemic disturbance during this period is thus likely to affect the developing dentition manifesting as a wide spectrum of defects in the enamel, dentin, or overall tooth morphology. Clinically, these often present as discoloration causing aesthetic concerns, tooth sensitivity, increased caries susceptibility, the risk for pulpal involvement, and its sequelae. Various authors have attempted to identify the range of environmental stressors that lead to such defects, but no definite etiology has yet been established. Further research is warranted to better understand these entities, improving their predictability and thus, aiding in timely diagnosis and successful treatment of the defects.


HTML PDF Share
  1. Bei M. Molecular genetics of tooth development. Curr Opin Genet Dev 2009;19(5):504–510. DOI: 10.1016/j.gde.2009.09.002
  2. Crombie F, Manton D. Aetiology of molar–incisor hypomineralization: a critical review. Int J Paediatr Dent 2009;19(2):73–83. DOI: 10.1111/j.1365-263X.2008.00966.x
  3. Jalevik B, Klingberg GA. Dental treatment, dental fear and behaviour management problems in children with severe enamel hypomineralization of their permanent first molars. Int J Paediatr Dent 2002;12(1):24–32.
  4. Alaluusua S. Aetiology of molar-incisor hypomineralisation: a systematic review. Eur Arch Paediatr Dent 2010;11(2):53–58. DOI: 10.1007/BF03262713
  5. MacDougall M, Simmons D, Luan X, et al. Dentin phosphoprotein and dentin sialoprotein are cleavage products expressed from a single transcript coded by a gene on human chromosome 4. Dentin phosphoprotein DNA sequence determination. J Biol Chem 1997;272(2):835–842. DOI: 10.1074/jbc.272.2.835.
  6. Witkop CJ, Rao S. Inherited Defects in Tooth Structure. Baltimore, Williams and Wilkins; 1971:153
  7. Kim JW, Simmer JP. Hereditary dentin defects. J Dent Res 2007;86(5):392–399. DOI: 10.1177/154405910708600502
  8. Witkop CJ. Hereditary defects in enamel and dentin. Acta Genet Stat Med 1957;7(1):236–239. DOI: 10.1159/000150974
  9. Bonaventure J, Stanescu R, Stanescu V, et al. Type II collagen defect in two sibs with the Goldblatt syndrome, a chondrodysplasia with dentinogenesis imperfecta, and joint laxity. Am J Med Genet A 1992;44(6):738–753. DOI: 10.1002/ajmg.1320440607
  10. Witt CVA, Hirt T, Rutz G, et al. Root malformation associated with a cervical mineralized diaphragm - a distinct form of tooth abnormality? Oral Surg Oral Med Oral Pathol Oral Radiol 2014;117(4):e311–e319. DOI: 10.1016/j.oooo.2013.06.030
  11. Lee HS, Kim SH, Kim SO, et al. A new type of dental anomaly: molarincisor malformation (MIM). Oral Surg Oral Med Oral Pathol Oral Radiol 2014;118(1):101–109.e3. DOI: 10.1016/j.oooo.2014.03.014
  12. Wright JT, Curran A, Kim KJ, et al. Molar root-incisor malformation: considerations of diverse developmental and etiologic factors. Oral Surg Oral Med Oral Pathol Oral Radiol 2016;121(2):164–172. DOI: 10.1016/j.oooo.2015.08.024
  13. Huang XF, Chai Y. Molecular regulatory mechanism of tooth root development. Int J Oral Sci 2012;4(4):177–181. DOI: 10.1038/ijos.2012.61
  14. Ford D, Seow WK, Kazoullis S, et al. A controlled study of risk factors for enamel hypoplasia in the permanent dentition. Pediatr Dent 2009;31(5):382–388.
  15. Tapias-Ledesma MA, Jiménez R, Lamas F, et al. Factors associated with first molar dental enamel defects: a multivariate epidemiological approach. ASDC J Dent Child 2003;70(3):215–220.
  16. Suckling GW, Herbison GP, Brown RH. Etiological factors influencing the prevalence of developmental defects of dental enamel in nine-year-old New Zealand children participating in a health and development study. J Dent Res 1987;66(9):1466–1469. DOI: 10.1177/00220345870660091101
  17. Hong L, Levy SM, Warren JJ, et al. Association of amoxicillin use during early childhood with developmental tooth enamel defects. Arch Pediatr Adolesc Med 2005;159(10):943–948. DOI: 10.1001/archpedi.159.10.943
  18. Whatling R, Fearne J. Molar incisor hypomineralization: a study of aetiological factors in a group of UK children. Int J Paediatr Dent 2008;18(3):155–162. DOI: 10.1111/j.1365-263X.2007.00901.x
  19. Arrow P. Risk factors in the occurrence of enamel defects of the first permanent molars among schoolchildren in Western Australia. Community Dent Oral Epidemiol 2009;37(5):405–415. DOI: 10.1111/j.1600-0528.2009.00480.x
  20. Suckling G, Pearce E. Developmental defects of enamel in a group of New Zealand children: their prevalence and some associated etiological factors. Community Dent Oral Epidemiol 1984;12(3):177–184. DOI: 10.1111/j.1600-0528.1984.tb01434.x
  21. Holta P, Alaluusua S, Saarinen-Pihkala UM, et al. Longterm adverse effects on dentition in children with poor risk neuroblastoma treated with high dose chemotherapy and autologous stem cell transplantation with or without total body irradiation. Bone Marrow Transplant 2002;29(2):121–127. DOI: 10.1038/sj.bmt.1703330
  22. Cubukcu CE, Sevinir B, Ercan I. Disturbed dental development of permanent teeth in children with solid tumors and lymphomas. Pediatr Blood Cancer 2012;58(1):80–84. DOI: 10.1002/pbc.22902
  23. Brin I, Zilberman Y, Galili D, et al. Eruption of rootless teeth in congenital renal disease. Oral Surg Oral Med Oral Pathol 1985;60(1):61–64. DOI: 10.1016/0030-4220(85)90217-8
  24. Lauer BJ, Spector ND. Hyperbilirubinemia in the newborn. Pediatr Rev 2011;32(8):341–349. DOI: 10.1542/pir.32-8-341
  25. Wan A, Daud SM, Teh S, et al. Management of neonatal jaundice in primary care. Malays Fam Physician 2016;11(2-3):16–19.
  26. Lygidakis NA, Dimou G, Marinou D. Molar-incisor-hypomineralisation (MIH). A retrospective clinical study in Greek children. II. Possible medical aetiological factors. Eur Arch Paediatr Dent 2008;9(4):207–217. DOI: 10.1007/BF03262637
  27. Apgar V. Proposal for a new method of evaluation of the newborn infant. Curr Res Anesth Analg 1953;32(4):260–267.
  28. Casey BM, McIntire DD, Leveno KJ. The continuing value of the Apgar score for the assessment of newborn infants. N Engl J Med 2001;344(7):467–471. DOI: 10.1056/NEJM200102153440701
  29. Finster M, Wood M. The Apgar score has survived the test of time. Anesthesiology 2005;102(4):855–857. DOI: 10.1097/00000542-200504000-00022
  30. Pascon T, Barbosa AMP, Cordeiro RCL, et al. Prenatal exposure to gestational diabetes mellitus increases developmental defects in the enamel of offspring. PLoS One 2019 14(2):e0211771. DOI: 10.1371/journal.pone.0211771
  31. Vucic S, Korevaar TIM, Dhamo B, et al. Thyroid function during early life and dental development. J Dent Res 2017;96(9):1020-1026. DOI: 10.1177/0022034517708551
  32. Yokohama-Tamaki T, Ohshima H, Fujjiwara N, et al. Cessation of Fgf10 signalling resulting in a defective dental epithelial stem cell compartment leads to the transition from crown to root formation. Development 2006:133(7):1359–1366. DOI: 10.1242/dev.02307
  33. Haq IZ, Akmal S, Chandler CL, et al. Review of practices in myelomeningocoele repair at King's College hospital, London. Br J Neurosurg 2012;26(6):851–855.
  34. Luder HU. Malformation of the tooth root in humans. Front Physiol 2015;6:307. DOI: 10.3389/fphys.2015.00307
  35. Rice F, Lewis A, Harold G, et al. Agreement between maternal report and antenatal records for a range of pre and perinatal factors: the influence of maternal and child characteristics. Early Hum Dev 2007;83(8):497–504. DOI: 10.1016/j.earlhumdev.2006.09.015
  36. Liu J, Tuvblad C, Li L, et al. Medical record validation of maternal recall of pregnancy and birth events from a twin cohort. Twin Res Hum Genet 2013;16(4):845–860. DOI: 10.1017/thg.2013.31
  37. Tienboon P, Rutishauser IH, Wahlqvist ML. Maternal recall of infant feeding practices after an interval of 14 to 15years. Aust J Nutr Diet 1994;51(1):25–27.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.