The role of athlete biological passport (ABP) is the longitudinal tracking of the doping biomarkers. There are three modules of this program: hematological, steroidal, and endocrinological. As of now, only the first two modules have been executed. The ABP program has become stronger since the introduction of the hematological module and is a vital instrument to combat doping malpractices. Since the ABP program focuses on the longitudinal tracking of various parameters that are affected by the use of performance-enhancing substances, it may be called an indirect tool for the detection of doping. The Athlete Passport Management Unit (APMU) linked with the laboratories performing the antidoping testing takes care of the administrative side of this program for ensuring an unbiased analysis of the outcomes after the evaluation of the passport. The results of the ABP profile of an athlete might be influenced due to some factors leading to misinterpretation of the data, which is a challenge for the authorities and needs to be looked upon. It is an important tool in the fight against doping. Recent developments in metabolomics show the ABP's tremendous potential. ABP's further progress with close analysis of biological parameters is now the most effective approach to stop athletes using undetectable banned substances.