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VOLUME 55 , ISSUE 3 ( July-September, 2021 ) > List of Articles

EDITORIAL

Angiogenic Biomarkers and Their Diagnostic and Therapeutic Role in Pregnancy

Shalini Gainder, Shivani A Anand

Keywords : Angiogenesis, Artificial reproductive technology, Biomarkers, Placenta, Pregnancy, Uteroplacental insufficiency

Citation Information :

DOI: 10.5005/jp-journals-10028-1451

License: CC BY-NC 4.0

Published Online: 00-09-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Angiogenic biomarkers are polypeptide molecules produced in the trophoblast and endothelial cells of the placenta which regulate important pregnancy-related processes such as implantation, remodeling of spiral arteries, development of tertiary villi, and optimum exchange of nutrients and oxygen between the fetus and the mother. When measured in the early trimester, it helps in predicting adverse pregnancy outcomes and in the third trimester it helps in tailoring antenatal monitoring in women with a myriad of pregnancy-related problems. With more than one women having pregnancies at an older age and with the use of artificial reproductive technology, most pregnancies will have high-risk factors. Angiogenic markers open up a lot of opportunities for obstetricians to be more alert and identify red flag signs and reduce iatrogenic prematurity and perinatal morbidity and mortality.


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