Peripheral limb gangrene in neonates presenting soon after birth is rare and exact etiology could not be ascertained in majority. In order to make an important contribution to the limited literature on this topic, we report rare and unique presentation of peripheral limb gangrene in two neonates soon after birth (on day 1 of life) involving lower limbs. The etiology could not be ascertained, despite extensive workup. Both cases were managed with supportive care and low-molecular-weight heparin and developed auto-amputation of toes.
Turnpenny PD, Stahl S, Bowers D, et al. Peripheral ischaemia and gangrene presenting at birth. Eur J Pediatr 1992;151(8):550–554. DOI: 10.1007/BF01957717.
Bhettay E, Jacobs ME. Peripheral gangrene in the newborn. A case description, and a discussion of possible mechanisms of origin. Clin Pediatr (Phila) 1977;16(6):573–576. DOI: 10.1177/000992287701600617.
Dogra S, Agrawal SK, Jindal R, et al. Peripheral gangrene in a breast fed neonate–is hypernatremic dehydration the cause? Indian J Pediatr 2011;78(12):1543–1545. DOI: 10.1007/s12098-011-0418-9.
Glaun BP, Weinberg EG, Malan AF. Peripheral gangrene in a newborn. Arch Dis Child 1971;46(245):105–107. DOI: 10.1136/adc.46.245.105.
Letts M, Blastorah B, al-Azzam S. Neonatal gangrene of the extremities. J Pediatr Orthop 1997;17(3):397–401. DOI: 10.1097/01241398-199705000-00023.
Singh J, Rattan KN, Gathwala G, et al. Idiopathic unilateral lower limb gangrene in a neonate. Indian J Dermatol 2011;56(6):747–748. DOI: 10.4103/0019-5154.91845.
Onalo R, Ogala WN, Lawal YZ, et al. Congenital gangrene of the extremities in a newborn. Niger J Clin Pract 2011;14(2):245–248. DOI: 10.4103/1119-3077.84031.
Kothari PR, Gupta A, Kulkarni B. Neonatal lower extremity gangrene. Indian Pediatr 2005;42(11):1156–1158.
Nagai MK, Littleton AG, Gabos PG. Intrauterine gangrene of the lower extremity in the newborn: a report of two cases. J Pediatr Orthop 2007;27(5):499–503. DOI: 10.1097/01.bpb.0000279024.88751.7d.
Ahluwalia J, Naseem S, Singh S, et al. Prothrombotic profile in children with peripheral gangrene: a single center experience. Clin Appl Thromb Hemost 2011;17(5):497–501. DOI: 10.1177/1076029610376627.