Journal of Postgraduate Medicine, Education and Research

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VOLUME 56 , ISSUE 3 ( July-September, 2022 ) > List of Articles

CASE REPORT

Disseminated Nocardiosis in a Patient with Steroid-dependent Nephrotic Syndrome

Jasmine Sethi, Tom Kakkanattu, Harsimran Kaur, Harbir Singh Kohli

Keywords : Brain abscess, Nephrotic syndrome, Nocardiosis

Citation Information : Sethi J, Kakkanattu T, Kaur H, Kohli HS. Disseminated Nocardiosis in a Patient with Steroid-dependent Nephrotic Syndrome. J Postgrad Med Edu Res 2022; 56 (3):129-130.

DOI: 10.5005/jp-journals-10028-1576

License: CC BY-NC 4.0

Published Online: 01-10-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Aim: We aim to describe an unusual case of disseminated nocardiosis in a patient with steroid-dependent nephrotic syndrome and its successful management with medical therapy alone. Background: Nocardia infection is uncommon in clinical practice, with most cases occurring as the result of opportunistic infection in immunocompromised patients. Here, we report a case of disseminated nocardiosis with brain abscesses in a patient with nephrotic syndrome. Case description: We report a middle-aged female with steroid-dependent nephrotic syndrome with disseminated nocardiosis. The patient was managed with imipenem/cilastatin, oral trimethoprim/sulfamethoxazole (TMP/SMX), and amikacin for 4 weeks followed by dual therapy with co-amoxiclav and TMP/SMX for 6 months. The patient had both clinical and radiological recovery. Clinical significance: The present case indicates the risk of life-threatening infection in patients receiving steroids and the need for prophylactic therapy to prevent serious infections during the course of steroid therapy.


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