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VOLUME 46 , ISSUE 2 ( April-June, 2012 ) > List of Articles

Symposium

Hematopoietic Stem Cell Applications: Past, Present and Future

Subhash Varma, Deepesh P Lad

Citation Information : Varma S, Lad DP. Hematopoietic Stem Cell Applications: Past, Present and Future. J Postgrad Med Edu Res 2012; 46 (2):69-74.

DOI: 10.5005/jp-journals-10028-1016

Published Online: 01-03-2014

Copyright Statement:  Copyright © 2012; The Author(s).


Abstract

Key messages

Hematopoietic stem cells possess the characteristics of self renewal, differentiation, mobilization and apoptosis.

The transfer of hematopoietic stem cells to rescue a recipient's hematopoiesis, who has received conditioning with high dose chemotherapy and/or total body irradiation, constitutes hematopoietic stem cell transplantation (HSCT).

Hematopoietic stem cells can be obtained from the bone marrow, peripheral blood or umbilical cord blood.

Autologous HSCT involves the infusion of one's own hematopoietic stem cells. An allogeneic HSCT involves the infusion of hematopoietic stem cells from another individual.

Depending on the HLA match, the HSCT is of following types: Syngeneic, matched related, matched unrelated and haploidentical.

Patient selection and the timing of transplant are the most important factors determining transplant outcomes.

Hematopoietic stem cells and umbilical cord stem cells have applications in regenerative medicine as shown in preclinical and early clinical studies.

 

How to cite this article

Lad DP, Malhotra P, Varma S. Hematopoietic Stem Cell Applications: Past, Present and Future. J Postgrad Med Edu Res 2012;46(2):69-74.


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