Journal of Postgraduate Medicine, Education and Research

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2013 | October-December | Volume 47 | Issue 4

EDITORIAL

SK Jindal

APPROACH TO MANAGEMENT OF TUBERCULOSIS - 2013

[Year:2013] [Month:October-December] [Volume:47] [Number:4] [Pages:1] [Pages No:0 - 0]

PDF  |  DOI: 10.5005/jpmer-47-4-v  |  Open Access |  How to cite  | 

RESEARCH ARTICLE

Ashim Das, Digambar Behera, Navneet Singh, Ashutosh N Aggarwal

Pleuropulmonary Tuberculosis Following Chemotherapy for Lung Cancer at a Tertiary Care Center in India

[Year:2013] [Month:October-December] [Volume:47] [Number:4] [Pages:4] [Pages No:177 - 180]

PDF  |  DOI: 10.5005/jp-journals-10028-1082  |  Open Access |  How to cite  | 

Abstract

Background

Chemotherapy is a risk factor for occurrence of infections. Tuberculosis is a common infection in high prevalence countries. Data on incidence of tuberculosis following lung cancer chemotherapy is limited. The current study was conducted to assess the spectrum and clinical profile of pleuro-pulmonary tuberculosis following lung cancer chemotherapy at a tertiary care institute in North India.

Methods

Retrospective data analysis of newly diagnosed lung cancer patients undergoing chemotherapy over a three-and-half year period. Diagnosis of tuberculosis was made by presence of suggestive clinicoradiological features (fever, cough, pleuritic chest pain, new parenchymal infiltrates or new onset pleural effusion on chest imaging) along with demonstration of acid fast bacilli (AFB) in sputum/pleural fluid/bronchoalveolar lavage (BAL) fluid and/or growth of Mycobacterium tuberculosis on culture. For biopsy/cytology specimens, tuberculosis was diagnosed by demonstration of granulomatous inflammation with AFB.

Results

Overall six (0.9%) of 662 lung cancer patients developed tuberculosis [four pulmonary (PTB) and two pleural (TB-PE)]. Occurrence of PTB/TB-PE and of smear-positive PTB after lung cancer chemotherapy was at a rate of 2.59 per 1000 patients/year and 1.73 per 1000 patients/year respectively, compared with national incidences of 1.85 per 1000 population/year and 0.75 per 1000 population/year respectively. Four patients had objective response to chemotherapy. Diagnosis of PTB/TB-PE was established by sputum microscopy, BAL fluid microscopy and pleural biopsy in two patients each. All patients developed tuberculosis on same side as primary tumor. All patients received standard four-drug anti-tubercular therapy (ATT). Median time interval between diagnosis of lung cancer and that of tuberculosis was 144 (56-317) days while time interval between last chemotherapy cycle and diagnosis of tuberculosis was 55 (36-182) days. Median overall survival and survival after diagnosis of tuberculosis were 312 (141-504) days and 174 (41-199) days respectively.

Conclusion

Occurrence of PTB/TB-PE after lung cancer chemotherapy is higher than the corresponding incidence of tuberculosis observed in the general Indian population. Overall survival of these patients is similar to lung cancer patients in general if clinical suspicion of tuberculosis is actively pursued and ATT initiated promptly following diagnosis of tuberculosis.

How to cite this article

Singh N, Madan K, Aggarwal AN, Gupta N, Das A, Behera D. Pleuropulmonary Tuberculosis Following Chemotherapy for Lung Cancer at a Tertiary Care Center in India. J Postgrad Med Edu Res 2013;47(4):177-180.

REVIEW ARTICLE

Kapil Goyal, Kusum Sharma, Suma B Appannanavar

Recent Advances in the Diagnosis of Tuberculosis

[Year:2013] [Month:October-December] [Volume:47] [Number:4] [Pages:7] [Pages No:181 - 187]

PDF  |  DOI: 10.5005/jp-journals-10028-1083  |  Open Access |  How to cite  | 

Abstract

How to cite this article

Sharma K, Appannanavar SB, Goyal K, Sharma A. Recent Advances in the Diagnosis of Tuberculosis. J Postgrad Med Edu Res 2013;47(4):181-187.

REVIEW ARTICLE

Ritika Kondel

Tuberculosis and Nanotechnology: Where shall the Twain meet?

[Year:2013] [Month:October-December] [Volume:47] [Number:4] [Pages:5] [Pages No:188 - 192]

PDF  |  DOI: 10.5005/jp-journals-10028-1084  |  Open Access |  How to cite  | 

Abstract

How to cite this article

Shafiq N, Kondel R, Malhotra S. Tuberculosis and Nanotechnology: Where shall the Twain meet? J Postgrad Med Edu Res 2013;47(4):188-192.

REVIEW ARTICLE

Swapnil Parchand, Vishali Gupta

Intraocular Tuberculosis

[Year:2013] [Month:October-December] [Volume:47] [Number:4] [Pages:9] [Pages No:193 - 201]

PDF  |  DOI: 10.5005/jp-journals-10028-1085  |  Open Access |  How to cite  | 

Abstract

How to cite this article

Parchand S, Gupta V, Gupta A, Sharma A. Intraocular Tuberculosis. J Postgrad Med Edu Res 2013;47(4):193-201.

REVIEW ARTICLE

Manish Modi, Abhishek Garg

Tuberculosis of Central Nervous System

[Year:2013] [Month:October-December] [Volume:47] [Number:4] [Pages:12] [Pages No:202 - 213]

PDF  |  DOI: 10.5005/jp-journals-10028-1086  |  Open Access |  How to cite  | 

Abstract

How to cite this article

Modi M, Garg A. Tuberculosis of Central Nervous System. J Postgrad Med Edu Res 2013;47(4):202-213.

CASE REPORT

Vidya Rattan, Sachin Rai

Tuberculosis of the Oral Cavity and Associated Structures: The PGIMER Experience

[Year:2013] [Month:October-December] [Volume:47] [Number:4] [Pages:4] [Pages No:214 - 217]

PDF  |  DOI: 10.5005/jp-journals-10028-1087  |  Open Access |  How to cite  | 

Abstract

How to cite this article

Rattan V, Rai S. Tuberculosis of the Oral Cavity and Associated Structures: The PGIMER Experience. J Postgrad Med Edu Res 2013;47(4):214-217.

CASE REPORT

Darwin Kaushal, Ravi Sankar, Amit Babel

Nasal Tuberculosis Mimicking Fungal Disease: A Rare Case Report

[Year:2013] [Month:October-December] [Volume:47] [Number:4] [Pages:3] [Pages No:218 - 220]

PDF  |  DOI: 10.5005/jp-journals-10028-1088  |  Open Access |  How to cite  | 

Abstract

How to cite this article

Virk RS, Kaushal D, Sankar R, Babel A. Nasal Tuberculosis Mimicking Fungal Disease: A Rare Case Report. J Postgrad Med Edu Res 2013;47(4):218-220.

RESEARCH ARTICLE

Devendra K Chouhan

Patellar Tuberculosis presenting as an Osteolytic Lesion

[Year:2013] [Month:October-December] [Volume:47] [Number:4] [Pages:2] [Pages No:221 - 222]

PDF  |  DOI: 10.5005/jp-journals-10028-1089  |  Open Access |  How to cite  | 

Abstract

How to cite this article

Chouhan DK, Dhillon MS, Prakash M, Sharma S. Patellar Tuberculosis Presenting as an Osteolytic Lesion. J Postgrad Med Edu Res 2013;47(4):221-222.

RESEARCH ARTICLE

Ashim Das, Nandita Kakkar, Sanjay Rathore, Abin Koshy, Umesh Kumar Chandel, A Bhansali

Disseminated Nonreactive Miliary Tuberculosis, Dual Infection with Mycobacterium tuberculosis/avium with Hemophagocytic Syndrome in a HIV-Positive Individual

[Year:2013] [Month:October-December] [Volume:47] [Number:4] [Pages:6] [Pages No:223 - 228]

PDF  |  DOI: 10.5005/jp-journals-10028-1090  |  Open Access |  How to cite  | 

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